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What Is Oxymorphone (Opana ER) 40mg?

Oxymorphone Hydrochloride 40mg extended-release, sold under the brand name Opana ER, is a potent semi-synthetic opioid approximately twice as potent as oral Morphine on a milligram-for-milligram basis. The 40mg extended-release formulation provides up to 12 hours of continuous, powerful pain relief, making it one of the most effective options for the around-the-clock management of severe chronic pain in opioid-tolerant adults.

Unlike Oxycodone, Oxymorphone does not produce an active Morphine metabolite, resulting in a cleaner pharmacokinetic profile and potentially fewer metabolite-related side effects in some patients — making it a preferred choice for those who have experienced problematic side effects with Morphine.

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Oxymorphone 40mg Uses

• Severe chronic pain requiring continuous around-the-clock opioid therapy
• Cancer pain requiring high-potency opioid management
• Severe neuropathic pain in opioid-tolerant patients
• Chronic low back pain unresponsive to lower-potency opioids
• Palliative care and end-of-life pain management
• Pain in patients for whom Morphine ER is inadequate

Oxymorphone 40mg Dosage

For opioid-tolerant adults ONLY. Dosing: one tablet every 12 hours. Swallow whole — NEVER crush or chew.
Critical food warning: Do NOT take with high-fat meals — food increases Oxymorphone absorption by up to 50%, significantly raising overdose risk. Always take on an empty stomach or with only a light, low-fat snack.

Oxymorphone vs Morphine, Oxycodone and Hydromorphone

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